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lumacaftor/ivacaftor will lower the level or result of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers minimizes plasma concentration of abemaciclib and its metabolites.Some Negative effects might occur that usually will not want healthcar